منابع مشابه
Pressure Denaturation of Proteins in Water: Revisiting a Heteropolymer Collapse Model
Understanding the environmental factors that cause proteins to unfold from their native conformations to form biologically-inactive or denatured states represents one of the most important challenges in the biological and pharmaceutical sciences. Although it has been known for some time that proteins can be denatured by heating or cooling at high or low pressure, only semiempirical thermodynami...
متن کاملHeteropolymer Folding
8 Heteropolymer Folding among the nite T landscape and the one at T = 0. One nds that the structure of the minima does not change much from T = 1 to T = 0, for example. The free energy landscape is quite stable. 16 is a SIMD parallel super-computer. In the tube version, the one we have used here, it has a theoretical speed of 6:5 GGops (and, as we will discuss , reaches an unusually high sustai...
متن کاملRandom heteropolymer dynamics.
We study the Langevin dynamics of the standard random heteropolymer model by mapping the problem to a supersymmetric field theory using the Martin-Siggia-Rose formalism. The resulting model is solved nonperturbatively employing a Gaussian variational approach. In constructing the solution, we assume that the chain is very long and impose the translational invariance which is expected to be pres...
متن کاملOn Heteropolymer Shape Dynamics
We investigate the time evolution of the heteropolymer model introduced by Iori, Marinari and Parisi to describe some of the features of protein folding mechanisms. We study how the (folded) shape of the chain evolves in time. We find that for short times the mean square distance (squared) between chain configurations evolves according to a power law, D ∼ tν . We discuss the influence of the qu...
متن کاملHeteropolymer translocation through nanopores.
The authors investigate the translocation dynamics of heteropolymers driven through a nanopore using a constant temperature Langevin thermostat. Specifically, they consider heteropolymers consisting of two types of monomers labeled A and B, which are distinguished by the magnitude of the driving force that they experience inside the pore. From a series of studies on polymers with sequences AmBn...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The European Physical Journal E
سال: 2000
ISSN: 1292-8941
DOI: 10.1007/pl00013672